Tafinlar Dabrafenib

Tafinlar Dabrafenib
Tafinlar Dabrafenib
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    Product Description
    Tafinlar (Dabrafenib)
    • Brand name: Tafinlar
    • Active Ingeridents (Generic Name) : DABRAFENIB
    • Company Name:Glaxosmithkline
    • Package: 120 capsules
    • Strength :  50mg


    Tafinlar (Dabrafenib)  is used to treat a certain type of metastatic melanoma (skin cancer that has spread to other parts of the body).  Tafinlar (Dabrafenib) is a cancer medication that interferes with the growth and spread of cancer cells in the body.

    Mechanism of action:

    Tafinlar (Dabrafenib) is an inhibitor of some mutated forms of BRAF kinases with in vitro IC50 values of 0.65, 0.5, and 1.84 nM for BRAF V600E, BRAF V600K, and BRAF V600D enzymes, respectively. Tafinlar (Dabrafenib) also inhibits wild-type BRAF and CRAF kinases with IC50 values of 3.2 and 5.0 nM, respectively, and other kinases such as SIK1, NEK11, and LIMK1 at higher concentrations. Some mutations in the BRAF gene, including those that result in BRAF V600E, can result in constitutively activated BRAF kinases that may stimulate tumor cell growth.

    Dosage & Administration:

    Tafinlar (Dabrafenib) is usually taken twice daily. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

    Your doctor will perform blood tests to make sure you have the correct tumor type to be treated with this medicine.

    Take Tafinlar (Dabrafenib) on an empty stomach, at least 1 hour before or 2 hours after a meal.

    Do not crush, chew, break, or open a capsule. Swallow it whole.

    If you need surgery, dental work, or a medical procedure, tell the doctor ahead of time that you are using Tafinlar (Dabrafenib).

    Your doctor will need to check your skin every 2 months while you are using Tafinlar (Dabrafenib), and for up to 6 months after your treatment ends.

    Side effects:

    Hair loss, thickening of the outer layers of the skin, headache, swelling/peeling of feet/hands, and joint/muscle/back pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

    Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.


    Before taking Tafinlar (Dabrafenib), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

    Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain enzyme deficiency (G6PD deficiency), liver disease, diabetes.

    Store: Store at room temperature away from moisture and heat.

    Trade Information
    • As Per Order Requirement Per Day
    • 1-12 Days
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