Reditux Rituximab

Reditux  ( Rituximab )

• Brand name: Reditux
• Active Ingeridents(Generic Name) : Retuximab Injection
• Company Name: Dr.Reddys
• Package: 1 Vial
• Strength : 100mg

Indication:  

Reditux ( Rituximab ) is used alone or with other medications to treat certain types of cancer (e.g., non-Hodgkin's lymphoma, chronic lymphocytic leukemia). It is a type of medication called a monoclonal antibody. It works by attaching to certain blood cells from your immune system (B cells) and killing them. It is also used with other monoclonal antibodies and radioactive drugs to treat certain cancers.

Reditux ( Rituximab ) is also used with methotrexate to treat moderate-to-severe forms ofrheumatoid arthritis. It is usually used for arthritis only after other medications have not worked. It can decrease joint pain and swelling. It is also used to treat certain types of blood vessel disease (such as Wegener's granulomatosis, microscopic polyangiitis).

Mechanism of action:
The antibody binds to CD20. CD20 is widely expressed on B cells, from early pre-B cells to later in differentiation, but it is absent on terminally differentiated plasma cells. CD20 does not shed, modulate or internalise. Although the function of CD20 is unknown, it may play a role in Ca2+ influx across plasma membranes, maintaining intracellular Ca2+ concentration and allowing activation of B cells.

Dosage and Administration:

Reditux ( Rituximab ) is administered by intravenous infusion. Patients should receive acetaminophen (Tylenol) and an antihistamine prior to the infusion to reduce the severity of infusion reactions.

Non-Hodgkin's B-cell lymphomas: 375 mg/m2 weekly for 4 to 8 weeks or longer.

Chronic lymphocytic leukemia: 375 mg/m2 for the first cycle then 500 mg/m2 every 28 days for cycles 2 to 6.

Wegener's granulomatosis or microscopic polyangiitis: 375 mg/m2

Rheumatoid arthritis: Two 1000 mg infusions are administered two weeks apart and then are repeated every 16 to 24 weeks.

Side effects:

Headache, fever, chills, nausea, heartburn, flushing, weakness, or dizziness may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: back/joint/muscle pain, increased thirst/urination, swelling of the hands/feet, tingling of the hands/feet.

Precaution:

Before using Reditux ( Rituximab ), tell your doctor or pharmacist if you are allergic to it; or to other mouse protein medications; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:

Reditux ( Rituximab ) should be stored at 2 C - 8 C (36 F - 36 F) and protected from sunlight.