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Imatib Imatinib

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Imatib Imatinib
Imatib Imatinib
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    Product Description

    Imatib  (Imatinib)

    • Brand name:    Imatib
    • Active Ingeridents(Generic Name) : Imatinib
    • Company Name :  Cipla
    • Package:  10 Tabs in strip
    • Strength : 100mg

    Indication:  

    This medication is used to treat certain types of cancer (such as acute lymphoblastic leukemia, chronic myeloid leukemia, gastrointestinal stromal tumors, and myelodysplastic/myeloproliferative diseases). It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.

    Mechanism of action:

    Imatib (Imatinib) is a 2-phenyl amino pyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. It occupies the TK active site, leading to a decrease in activity.There are a large number of TK enzymes in the body, including the insulin receptor. Imatib (Imatinib) is specific for the TK domain in abl(the Abelson proto-oncogene), c-kit and PDGF-R (platelet-derived growth factor receptor).In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of abl with bcr(breakpoint cluster region), termed bcr-abl. As this is now aconstitutively active tyrosine kinase, Imatib (Imatinib) is used to decrease bcr-abl activity.The active sites of tyrosine kinases each have a binding site for ATP. The enzymatic activity catalyzed by a tyrosine kinase is the transfer of the terminal phosphate from ATP to tyrosine residues on its substrates, a process known as protein tyrosinephosphorylation.

    Dosage and Administration:

    Take the medicine with a large glass of water and food.  This will help to avoid irritating the lining of your oesophagus (food pipe) and stomach.

    Side Effects:

    The most common side effects include feeling sick (nausea), diarrhea, headaches, leg aches/cramps, fluid retention, visual disturbances, itchy rash, lowered resistance to infection, bruising or bleeding, loss of appetite; weight gain, reduced number of blood cells (neutropeniathrombocytopeniaanemia), and edema. Although rare, restoration of hair color has been reported as well. Severecongestive cardiac failure is an uncommon but recognized side effect of Imatib (Imatinib) and mice treated with large doses of Imatib (Imatinib) show toxic damage to their myocardium.

    Precaution:

    The only known contraindication to Imatib (Imatinib) is hypersensitivity to Imatib (Imatinib). Cautions include:

    • Hepatic impairment
    • Risk of severe CHF or left ventricular dysfunction, especially in patients with comorbidities
    • Pregnancy, risk of embryo-fetal toxicity
    • Risk of fluid retention
    • Risk of growth stunting in children or adolescents

    Store:  Imatib (Imatinib)  room temperature away from moisture and heat.



    Trade Information
    • As Per Order Requirement Per Day
    • 1-12 Days
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